Unknown peptide sequencing using matrix-assisted laser desorption/ionization and in-source decay.

@article{Reiber1998UnknownPS,
  title={Unknown peptide sequencing using matrix-assisted laser desorption/ionization and in-source decay.},
  author={Duane Reiber and Robert S. Brown and Scot Weinberger and John Kenny and Jonathan Bailey},
  journal={Analytical chemistry},
  year={1998},
  volume={70 6},
  pages={1214-22}
}
The results of a study to determine the utility of in-source decay fragmentation of matrix-assisted laser-desorbed ions for obtaining useful sequence information on unknown peptides are presented. Six peptides were purified by high-performance liquid chromatography and submitted as single blind unknowns. The in-source decay fragment ion data were collected on a linear time-of-flight mass spectrometer equipped with delayed extraction. These fragment ion data were manually interpreted on the… CONTINUE READING

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