University of Groningen Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes , with a major role for the


For many complex traits, genetic variants have been found associated. However, it is still mostly unclear through which downstream mechanism these variants cause these phenotypes. Knowledge of these intermediate steps is crucial to understand pathogenesis, while also providing leads for potential pharmacological intervention. Here we relied upon natural… (More)

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