University of Groningen Identification of a BRCA 2-Specific Modifier Locus at 6 p 24 Related to Breast Cancer

  title={University of Groningen Identification of a BRCA 2-Specific Modifier Locus at 6 p 24 Related to Breast Cancer},
  author={Mia M. Gaudet and Karoline B Kuchenbaecker and Joseph Vijai and Robert J. Klein and Tomas Kirchhoff and Lesley McGuffog and Daniel Barrowdale and Alison M. Dunning and Andrew Lee and Joe Dennis and Sue Healey and Ed Dicks and Penny Soucy and Olga Sinilnikova and V. Shane Pankratz and Xianshu Wang and Ronald Curtis Eldridge and Daniel C. Tessier and Daniel D Vincent and François Bacot and Frans Hogervorst and Susan Peock and Dominique Stoppa-Lyonnet and Paolo Peterlongo and Rita Katharina Schmutzler and Katherine L Nathanson and M. Piedmonte and Christian Singer and Mads Thomassen and Thomas v. O. Hansen and Susan L. Neuhausen and Ignacio Blanco and Mark H Greene and Judith Garber and Jeffrey N. Weitzel and Irene L Andrulis and David E. Goldgar and Emma D’Andrea and Trinidad Caldes and Heli Nevanlinna and A Osorio and Elizabeth J. van Rensburg and Adalgeir Arason and Gad Rennert and Ans M. W. van den Ouweland and Annemarie H. van der Hout and Carolien M. Kets and Cora M Aalfs and Juul Th Wijnen and Margreet G Ausems and Debra Frost and Steve Ellis and Elena Fineberg and Radka Platte and D Gareth R Evans and Chris Jacobs and Julian W. Adlard and Marc Tischkowitz and Mary E M Porteous and Lisa Golmard and Laure Barjhoux and Michel Longy and Muriel Belotti and Sandra Fert Ferrer and Sylvie Mazoyer and Amanda B Spurdle and Siranoush Manoukian and Monica Barile and Maurizio Genuardi and Norbert Arnold and Alfons Meindl and Christian Sutter and Barbara Wappenschmidt and Susan Domchek and Georg H Pfeiler and Eitan Friedman and Uffe Birk Jensen and Mark Robson and Sohela Shah and Conxi L{\'a}zaro and Phuong L. Mai and Javier Ben{\'i}tez and Melissa C. Southey and Marjanka K. Schmidt and Peter A. Fasching and Julian Peto and Manjeet K. Humphreys and Qin Wang and Kyriaki Michailidou and Elinor J. Sawyer and Barbara Burwinkel and Pascal Gu{\'e}nel and S E Bojesen and Roger L Milne and Magdalena Lochmann and Kristiina Aittom{\"a}ki and Thilo D{\"o}rk and Sara Margolin and Arto J Mannermaa and Diether Lambrechts and Paolo Radice and Graham G. Giles and Christopher A. Haiman and Nils Schoof and Maartje J. Hooning and Angela Cox and Paul P. D. Pharoah and Anna Jakubowska and Nick Orr and Anna Gonz{\'a}lez-Neira and Guillermo Pita and Maria Del Rosario Zariategui de Alonso and Per Hall and Fergus J. Couch and Jacques Simard and David Altshuler and Douglas F. Easton and Georgia Chenevix-Trench and Antonis C. Antoniou and Kenneth Offit},
Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through population-based genome-wide association studies (GWAS). To comprehensively identify breast cancer risk modifying loci for BRCA2 mutation carriers, we conducted a deep replication of an ongoing GWAS… CONTINUE READING