Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection.

@article{Bakkouri2011UniversalVB,
  title={Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection.},
  author={Karim El Bakkouri and Francis J Descamps and Marina De Filette and A. Smet and Els Festjens and Ashley Birkett and Nico Van Rooijen and Sjef S Verbeek and Walter Fiers and Xavier Saelens},
  journal={Journal of immunology},
  year={2011},
  volume={186 2},
  pages={1022-31}
}
The ectodomain of matrix protein 2 (M2e) of influenza A virus is an attractive target for a universal influenza A vaccine: the M2e sequence is highly conserved across influenza virus subtypes, and induced humoral anti-M2e immunity protects against a lethal influenza virus challenge in animal models. Clinical phase I studies with M2e vaccine candidates have been completed. However, the in vivo mechanism of immune protection induced by M2e-carrier vaccination is unclear. Using passive… CONTINUE READING
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