Universal molecular screening does not effectively detect Lynch syndrome in clinical practice

@inproceedings{Brennan2017UniversalMS,
  title={Universal molecular screening does not effectively detect Lynch syndrome in clinical practice},
  author={Beatrice Brennan and Christine T. Hemmings and Ian R Clark and Desmond Yip and Mitali Fadia and Douglas R. Taupin},
  booktitle={Therapeutic advances in gastroenterology},
  year={2017}
}
BACKGROUND Lynch syndrome (LS) due to an inherited damaging mutation in mismatch repair (MMR) genes comprises 3% of all incident colorectal cancer (CRC). Molecular testing using immunohistochemistry (IHC) for MMR proteins is a recommended screening tool to identify LS in incident CRC. This study assessed outcomes of population-based routine molecular screening for diagnosis of LS in a regional center. METHODS We conducted a prospective, consecutive case series study of universal IHC testing… CONTINUE READING

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