# Universal energy accuracy tradeoffs in nonequilibrium cellular sensing

@article{Harvey2020UniversalEA, title={Universal energy accuracy tradeoffs in nonequilibrium cellular sensing}, author={Sarah Harvey and Subhaneil Lahiri and Surya Ganguli}, journal={arXiv: Biological Physics}, year={2020} }

We combine stochastic thermodynamics, large deviation theory, and information theory to derive fundamental limits on the accuracy with which single cell receptors can detect external concentrations. We show that if estimation is performed by an ideal observer of the entire trajectory of receptor states, then no energy consuming non-equilibrium receptor that can be divided into signaling and non-signaling states can outperform an equilibrium two-state receptor. Moreover, we derive an energy…

## 5 Citations

### Size limits sensitivity in all kinetic schemes

- Biology
- 2021

In pursuit of mechanisms that saturate the support bound, this work finds a nonequilibrium binding mechanism, nested hysteresis, with sensitivity exponential in the number of binding sites, with implications for the understanding of models of gene regulation.

### Size limits the sensitivity of kinetic schemes

- BiologyNature Communications
- 2023

It is found that for any kinetic scheme, at or away from thermodynamic equilibrium, a very simple structural quantity, the size of the support of a perturbation, always limits the effective Hill coefficient.

### Cellular compartmentalisation and receptor promiscuity as a strategy for accurate and robust inference of position during morphogenesis

- BiologybioRxiv
- 2022

This work shows how cells may utilise multiple tiers of processing and parallel branches, together with feedback control, to bring about fidelity in morphogenetic decoding of their positions within a developing tissue by simultaneously deploying specific and nonspecific receptors.

### Measuring Entropy Production at the Mesoscale Theorists place bounds on the energy consumption of a mesoscopic nonequilibrium

- Physics
- 2021

Figure 1: Researchers have developed amodel that can place a lower bound on the energy consumption of a nonequilibrium system using the waiting time distribution of transitions between its…

### Estimating Entropy Production from Waiting Time Distributions.

- Computer SciencePhysical review letters
- 2021

A novel method for bounding the entropy production of physical and living systems which uses only the waiting time statistics of hidden Markov processes and can be directly applied to experimental data is introduced.

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