• Corpus ID: 211296859

Universal energy accuracy tradeoffs in nonequilibrium cellular sensing

  title={Universal energy accuracy tradeoffs in nonequilibrium cellular sensing},
  author={Sarah Harvey and Subhaneil Lahiri and Surya Ganguli},
  journal={arXiv: Biological Physics},
We combine stochastic thermodynamics, large deviation theory, and information theory to derive fundamental limits on the accuracy with which single cell receptors can detect external concentrations. We show that if estimation is performed by an ideal observer of the entire trajectory of receptor states, then no energy consuming non-equilibrium receptor that can be divided into signaling and non-signaling states can outperform an equilibrium two-state receptor. Moreover, we derive an energy… 

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