Universal constraints on selection strength in lineage trees

@inproceedings{Genthon2021UniversalCO,
  title={Universal constraints on selection strength in lineage trees},
  author={Arthur Genthon and D. Lacoste},
  year={2021}
}
We obtain general inequalities constraining the difference between the average of an arbitrary function of a phenotypic trait, which includes the fitness landscape of the trait itself, in the presence or in the absence of natural selection. These inequalities imply bounds on the strength of selection, which can be measured from the statistics of trait values and divisions along lineages. The upper bound is related to recent generalizations of linear response relations in Stochastic… Expand

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References

SHOWING 1-10 OF 36 REFERENCES
Quasi-species evolution maximizes genotypic reproductive value (not fitness or flatness)
TLDR
It is shown that another measure of reproductive success, Fisher’s reproductive value, resolves the trade-off between fitness and robustness in the quasi-species regime of evolution: to forecast the motion of a population in genotype space, one should look for peaks in the landscape of genotypic reproductive values, whether or not these peaks correspond to local fitness maxima or flat fitness plateaus. Expand
Fluctuation relations and fitness landscapes of growing cell populations
TLDR
The concept of fitness landscape is studied, which quantifies the correlations between a phenotypic trait of interest and the number of divisions, for age and size-controlled models. Expand
Fluctuation–response inequality out of equilibrium
  • A. Dechant, S. Sasa
  • Physics, Medicine
  • Proceedings of the National Academy of Sciences
  • 2020
TLDR
It is shown that for steady-state particle transport, the differential mobility is bounded by the diffusivity, and the FRI is used to derive a generalization of the uncertainty relation to arbitrary dynamics, which involves higher-order cumulants of the observable. Expand
Phase transitions in optimal betting strategies
L. Dinis1, J. Unterberger2 and D. Lacoste3 1 GISC Grupo Interdisciplinar de Sistemas Complejos and Dpto. de Estructura de la Materia, FÃŋsica TÃľrmica y ElectrÃşnica, Universidad Complutense deExpand
Price's equation made clear
  • A. Gardner
  • Mathematics, Medicine
  • Philosophical Transactions of the Royal Society B
  • 2020
TLDR
It is suggested that Price's equation is useful not primarily as a predictor of evolutionary change but because it provides a general theory of selection. Expand
High-resolution lineage tracking reveals traveling wave of adaptation in laboratory yeast
TLDR
A renewable barcoding system reveals the evolutionary dynamics of laboratory budding yeast, showing that fitness changes over time in a travelling wave of adaptation that can fluctuate owing to leapfrogging events. Expand
Linking lineage and population observables in biological branching processes
TLDR
It is argued that testing inequalities comparing the population doubling time with the mean generation time at the lineage or population levels provides useful insights into the underlying mechanism controlling the division rate in such branching processes. Expand
Simultaneous tracking of division and differentiation from individual hematopoietic stem and progenitor cells reveals within-family homogeneity despite population heterogeneity
TLDR
A high-throughput method is developed that enables simultaneously determination of common ancestor, generation, and differentiation status of a large collection of single cells and reveals cells that derived from a common ancestor were highly concordant in their division progression and share similar differentiation outcomes, revealing significant familial effects on both division and differentiation. Expand
Thermodynamic uncertainty relations constrain non-equilibrium fluctuations
In equilibrium thermodynamics, there exists a well-established connection between dynamical fluctuations of a physical system and the dissipation of its energy into an environment. However, fewExpand
Macroscopic Theory for Evolving Biological Systems Akin to Thermodynamics.
TLDR
A formulation of cellular systems akin to thermodynamics is suggested, in which a macroscopic potential is given by the growth rate (or fitness) represented as a function of environmental and evolutionary changes. Expand
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