Universal anti-neuraminidase antibody inhibiting all influenza A subtypes.

  title={Universal anti-neuraminidase antibody inhibiting all influenza A subtypes.},
  author={Tracey M Doyle and Anwar M Hashem and Changgui Li and Gary H Van Domselaar and Louise J. Larocque and Jun-Zhi Wang and Daryl L. Smith and Terry D. Cyr and Aaron Farnsworth and RunTao He and Aeron C. Hurt and Earl G. Brown and Xuguang Li},
  journal={Antiviral research},
  volume={100 2},
The only universally conserved sequence amongst all influenza A viral neuraminidase (NA) is located between amino acids 222-230 and plays crucial roles in viral replication. However, it remained unclear as to whether this universal epitope is exposed during the course of infection to allow binding and inhibition by antibodies. Using a monoclonal antibody (MAb) targeting this specific epitope, we demonstrated that all nine subtypes of NA were inhibited in vitro by the MAb. Moreover, the antibody… CONTINUE READING
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