Universal absence of merlin, but not other ERM family members, in schwannomas.

  title={Universal absence of merlin, but not other ERM family members, in schwannomas.},
  author={Anat Stemmer-Rachamimov and L Y Xu and Charo Gonzalez-Agosti and Jennifer Burwick and David Pinney and Roberta Beauchamp and Lee B. Jacoby and James F. Gusella and V Ramakrishnan Ramesh and David N Louis},
  journal={The American journal of pathology},
  volume={151 6},
NF2 (neurofibromatosis 2, encoding the merlin protein) gene mutations and chromosome 22q loss have been demonstrated in the majority of sporadic and NF2-associated schwannomas, but many schwannomas fail to demonstrate genetic evidence of biallelic NF2 gene inactivation. In addition, the role of the merlin-related ERM family members (ezrin, radixin, and moesin) remains unclear in these tumors. We therefore studied expression of NF2-encoded merlin as well as ezrin, radixin, and moesin in 22… CONTINUE READING

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