United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction.

@article{Schwarz2012UnitedWS,
  title={United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction.},
  author={Ulrich S. Schwarz and Margaret L. Gardel},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 13},
  pages={3051-60}
}
Many essential cellular functions in health and disease are closely linked to the ability of cells to respond to mechanical forces. In the context of cell adhesion to the extracellular matrix, the forces that are generated within the actin cytoskeleton and transmitted through integrin-based focal adhesions are essential for the cellular response to environmental clues, such as the spatial distribution of adhesive ligands or matrix stiffness. Whereas substantial progress has been made in… CONTINUE READING
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