United States Patent ( 19 ) Robey et al . ( 54 ) SYNTHESIS OF CHLOROACETYL AND BROMOACETYL MOD FED PEPTOES FOR THE PREPARATION OF SYNTHETIC PEPTIDE POLYMERS , CONJUGATED PEPTIDES , AND CYCLICPEPTIDES 75 ) Inventors :

@inproceedings{Robey2017UnitedSP,
  title={United States Patent ( 19 ) Robey et al . ( 54 ) SYNTHESIS OF CHLOROACETYL AND BROMOACETYL MOD FED PEPTOES FOR THE PREPARATION OF SYNTHETIC PEPTIDE POLYMERS , CONJUGATED PEPTIDES , AND CYCLICPEPTIDES 75 ) Inventors :},
  author={Frank A. Robey},
  year={2017}
}
A method to incorporate bronoacetyl and chloroacetyl moieties on amino groups of synthetic peptides using a standard program with an automated peptide synthe sizer has been developed. The bromoacetyl and chlo roacetyl-derivatized peptides react well with sulfhyd ryl-containing proteins and with peptides containing cysteine residues. Autopolymerization or cyclization occurs by reaction of the free sulfhydryl of cysteine in a peptide with the bromoacetyl group (or chloroacetyl group) and… CONTINUE READING