Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes.

@article{Collier1995UnitaryCC,
  title={Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes.},
  author={Martha L Collier and Joseph R. Hume},
  journal={Circulation research},
  year={1995},
  volume={76 2},
  pages={317-24}
}
Recent evidence suggests that protein kinase A (PKA)-activated Cl- channels in heart are encoded by an isoform of the epithelial cystic fibrosis transmembrane conductance regulator gene (CFTR). Macroscopic current measurements indicate that a similar time-independent Cl- conductance can be activated through a protein kinase C (PKC)-dependent pathway in guinea pig and feline ventricle. However, it is presently not clear whether PKC is activating the same population of channels as PKA or a… CONTINUE READING
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