Unique variation in genetic selection among Black North American women and its potential influence on pregnancy outcome.

@article{Jaffe2013UniqueVI,
  title={Unique variation in genetic selection among Black North American women and its potential influence on pregnancy outcome.},
  author={Shirlee Jaffe and Neil J Normand and Aswathi Jayaram and Theofano Orfanelli and Georgios Doulaveris and Mariana DL Passos and Tomi T. Kanninen and Ann Marie Bongiovanni and Iara Moreno Linhares and Steven S Witkin},
  journal={Medical hypotheses},
  year={2013},
  volume={81 5},
  pages={919-22}
}
We hypothesize that variations in the frequency of genetic polymorphisms, reflecting ancestral differences in living conditions and exposure to microorganisms, increase susceptibility to adverse pregnancy outcome among present day Black North American women. Striking differences were observed in the frequency of genetic variants between Black and White or Hispanic women in 5 genes (IL1RN, MBL2, PPARA, ATG16L1, CIAS1) associated with inflammation and anti-microbial immunity. The CIAS1 and IL1RN… CONTINUE READING