Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome.

@article{Akar2002UniqueTD,
  title={Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome.},
  author={Fadi Gabriel Akar and Gan Xin Yan and Charles Antzelevitch and David S. Rosenbaum},
  journal={Circulation},
  year={2002},
  volume={105 10},
  pages={1247-53}
}
BACKGROUND Specific ion channel mutations underlie the congenital long-QT syndrome (LQTS). However, the mechanisms by which dysfunction at the molecular level translates into functional electrical instability leading to torsade de pointes (TdP) in LQTS are poorly understood. METHODS AND RESULTS The cellular basis of TdP was investigated using a novel approach of transmural optical imaging in the canine wedge preparation (n=14). The spatial organization of repolarization and arrhythmogenesis… CONTINUE READING
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