Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations.

@article{Muzammil2007UniqueTR,
  title={Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations.},
  author={Salman Muzammil and Anthony A. Armstrong and Liew Woei Kang and Araz Jakalian and Pierre R. Bonneau and V. Schmelmer and L. Mario Amzel and Ernesto Freire},
  journal={Journal of virology},
  year={2007},
  volume={81 10},
  pages={5144-54}
}
Drug resistance is a major problem affecting the clinical efficacy of antiretroviral agents, including protease inhibitors, in the treatment of infection with human immunodeficiency virus type 1 (HIV-1)/AIDS. Consequently, the elucidation of the mechanisms by which HIV-1 protease inhibitors maintain antiviral activity in the presence of mutations is critical to the development of superior inhibitors. Tipranavir, a nonpeptidic HIV-1 protease inhibitor, has been recently approved for the… CONTINUE READING

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