Unique subset of natural killer cells develops from progenitors in lymph node.

@article{Veinotte2008UniqueSO,
  title={Unique subset of natural killer cells develops from progenitors in lymph node.},
  author={Linnea Lora Veinotte and Timotheus Y F Halim and Fumio Takei},
  journal={Blood},
  year={2008},
  volume={111 8},
  pages={4201-8}
}
Natural killer (NK) cells have been thought to develop from committed progenitors in the bone marrow. However, a novel pathway of thymus-dependent NK-cell development that produces a unique subset of NK cells expressing CD127 has recently been reported. We now have identified 2 populations of NK progenitors, one in the thymus and the other in the lymph node (LN). Immature double-negative 2 (CD4(-)CD8(-)CD44(+)CD25(+)) thymocytes have potential to produce NK cells with rearranged T-cell receptor… CONTINUE READING