Unique signal transduction of the VEGF family members VEGF-A and VEGF-E.

@article{Shibuya2009UniqueST,
  title={Unique signal transduction of the VEGF family members VEGF-A and VEGF-E.},
  author={Masabumi Shibuya},
  journal={Biochemical Society transactions},
  year={2009},
  volume={37 Pt 6},
  pages={1161-6}
}
Both VEGF (vascular endothelial growth factor)-A and Orf-virus-encoded VEGF-E bind and activate VEGFR (VEGF receptor)-2; however, only VEGF-A binds VEGFR-1. To understand the biological differences between VEGF-A and VEGF-E in vivo, we established transgenic mouse models. K14 (keratin-14)-promoter-driven VEGF-E transgenic mice showed a significant increase in mature blood vessels. However, K14-VEGF-A transgenic mice exhibited severe inflammation and oedema with increased angiogenesis, as well… CONTINUE READING
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