Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis

Abstract

AKT is a serine-threonine kinase that becomes hyperactivated in a number of cancers including lung cancer. Based on AKT's association with malignancy, molecules targeting AKT have entered clinical trials for solid tumors including lung cancer. However, the AKT inhibitors being evaluated in clinical trials indiscriminately inhibit all three AKT isoforms… (More)
DOI: 10.18632/oncotarget.6489

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