Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease.

@article{Vetrano2008UniqueRO,
  title={Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease.},
  author={Stefania Vetrano and Maria Rescigno and Maria Rosaria Cera and Carmen Correale and Cristiano Rumio and Andrea Doni and Massimo Claudio Fantini and Andreas Sturm and Elena Monica Borroni and Alessandro Repici and Massimo Locati and Alberto Malesci and Elisabetta Dejana and Silvio Danese},
  journal={Gastroenterology},
  year={2008},
  volume={135 1},
  pages={
          173-84
        }
}
BACKGROUND & AIMS Junctional adhesion molecule-A (JAM-A) is localized at the tight junctions and controls leukocyte migration into the tissues. However, its functional role in inflammatory bowel disease (IBD) is unexplored. METHODS Control, Crohn's disease (CD), and ulcerative colitis (UC) tissue specimens were studied for JAM-A expression, as well as the colon of mice given dextran sodium sulfate (DSS). Wild-type and JAM-A(-/-), Tie-2-Cre-JAM-A(-/-) (endothelial/hematopoietic-specific JAM… 

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