Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.

@article{Willy1997UniqueRF,
  title={Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.},
  author={Patricia J. Willy and David J Mangelsdorf},
  journal={Genes & development},
  year={1997},
  volume={11 3},
  pages={289-98}
}
LXR is an orphan nuclear receptor that confers retinoid responsiveness to the retinoid X receptor (RXR) by its interaction on a specific response element called an LXRE. To understand the mechanism of this response, three characteristics were identified that are crucial to activation of the RXR-LXR complex. First, the orientation of the RXR-LXR heterodimer on DNA indicates that as the ligand-binding partner, RXR occupies the 5' half-site of the response element. Next, the sequence specificity… CONTINUE READING
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