Unique renal tubule changes induced in rats and mice by the peroxisome proliferators 2,4-dichlorophenoxyacetic acid (2,4-D) and WY-14643.

@article{Ozaki2001UniqueRT,
  title={Unique renal tubule changes induced in rats and mice by the peroxisome proliferators 2,4-dichlorophenoxyacetic acid (2,4-D) and WY-14643.},
  author={Keisuke Ozaki and Joel F. Mahler and Joseph K. Haseman and Cindy R. Moomaw and Matthew L. Nicolette and Abraham Nyska},
  journal={Toxicologic pathology},
  year={2001},
  volume={29 4},
  pages={440-50}
}
Peroxisome proliferators are non-mutagenic carcinogens in the liver of rodents, acting both as initiators and promoters. The National Toxicology Program (NTP) conducted a study of several peroxisome proliferators (PPs), including Wyeth (WY)-14643 as a prototypical PP and 2,4-dichlorophenoxyacetic acid (2,4-D) as a weak PP, in Sprague-Dawley rats. B6C3F1 mice, and Syrian hamsters. In the kidney, an unusual change was observed in the outer stripe of the outer medulla, especially in rats treated… CONTINUE READING

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