Unique regulation of CCL18 production by maturing dendritic cells.

@article{Vulcano2003UniqueRO,
  title={Unique regulation of CCL18 production by maturing dendritic cells.},
  author={Marisa Vulcano and Sofie Struyf and Patrizia Scapini and Marco A Cassatella and S Bernasconi and Raffaella Bonecchi and Angelica Calleri and Giuseppe Penna and L. Adorini and Walter Luini and Alberto Mantovani and Jo Van Damme and Silvano Sozzani},
  journal={Journal of immunology},
  year={2003},
  volume={170 7},
  pages={3843-9}
}
Dendritic cells (DC) orchestrate the trafficking of lymphocytes by secreting chemokines with different specificity and function. Chemokines are produced at higher levels by mature DC. This study shows that CCL18 is one of the most abundant chemokines produced by immature DC. In contrast to all other chemokines investigated to date, CCL18 was selectively down-regulated during the maturation process induced by LPS, TNF, CD40 ligand, Staphylococcus aureus Cowan I, Candida albicans, and influenza… CONTINUE READING
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