Unique reciprocal changes of hepatocellular membrane transporter expression and fluidity in rats with selective biliary obstruction.

@article{Kanno2003UniqueRC,
  title={Unique reciprocal changes of hepatocellular membrane transporter expression and fluidity in rats with selective biliary obstruction.},
  author={Keishi Kanno and Susumu Tazuma and Shumpei Niida and Kazuaki Chayama},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2003},
  volume={26 2},
  pages={157-163}
}
BACKGROUND AND AIMS: The localized occlusion of bile ducts by intrahepaticlithiasis and intrahepatic neoplasms dose not cause severe jaundice, although the reason is unclear. The aim of this study was to clarify the molecular change of the liver in partial cholestasis, especially with respect to transporter expression (Mrp2, Mrp3, Bsep, P-gps) and membrane fluidity. METHODS AND RESULTS: After 3 days of selective bile duct ligation in Sprague-Dawley rats, the obstructed lobe (OL) and non-OL were… CONTINUE READING