Unique properties of R-type calcium currents in neocortical and neostriatal neurons.

@article{Foehring2000UniquePO,
  title={Unique properties of R-type calcium currents in neocortical and neostriatal neurons.},
  author={Robert C. Foehring and Paul G Mermelstein and Wen-Jie Song and S Ulrich and D. James Surmeier},
  journal={Journal of neurophysiology},
  year={2000},
  volume={84 5},
  pages={2225-36}
}
Whole cell recordings from acutely dissociated neocortical pyramidal neurons and striatal medium spiny neurons exhibited a calcium-channel current resistant to known blockers of L-, N-, and P/Q-type Ca(2+) channels. These R-type currents were characterized as high-voltage-activated (HVA) by their rapid deactivation kinetics, half-activation and half-inactivation voltages, and sensitivity to depolarized holding potentials. In both cell types, the R-type current activated at potentials relatively… CONTINUE READING