Unique physicochemical profile of beta-amyloid peptide variant Abeta1-40E22G protofibrils: conceivable neuropathogen in arctic mutant carriers.

@article{Pivi2004UniquePP,
  title={Unique physicochemical profile of beta-amyloid peptide variant Abeta1-40E22G protofibrils: conceivable neuropathogen in arctic mutant carriers.},
  author={Anna P{\"a}ivi{\"o} and Jyri Jarvet and Astrid Gr{\"a}slund and Lars Lannfelt and Anita Westlind-Danielsson},
  journal={Journal of molecular biology},
  year={2004},
  volume={339 1},
  pages={145-59}
}
A new early-onset form of Alzheimer's disease (AD) was described recently where a point mutation was discovered in codon 693 of the beta-amyloid (Abeta) precursor protein gene, the Arctic mutation. The mutation translates into a single amino acid substitution, glutamic acid-->glycine, in position 22 of the Abeta peptide. The mutation carriers have lower plasma levels of Abeta than normal, while in vitro studies show that Abeta1-40E22G protofibril formation is significantly enhanced. We have… CONTINUE READING
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