Unique patterns of gene expression changes in liver after treatment of mice for 2 weeks with different known carcinogens and non-carcinogens.

@article{Iida2005UniquePO,
  title={Unique patterns of gene expression changes in liver after treatment of mice for 2 weeks with different known carcinogens and non-carcinogens.},
  author={Mari Iida and Colleen H. Anna and Wanda M Holliday and Jennifer Brady Collins and Michael L. Cunningham and Robert C. Sills and Theodora R. Devereux},
  journal={Carcinogenesis},
  year={2005},
  volume={26 3},
  pages={689-99}
}
Previously we demonstrated that the mouse liver tumor response to the non-genotoxic carcinogens oxazepam and Wyeth-14,643 involved more differences than similarities in changes in early gene expression. In this study we used quantitative real-time PCR and oligonucleotide microarray analysis to identify genes that were up- or down-regulated in mouse liver early after treatment with different known carcinogens, including oxazepam (125 and 2500 p.p.m.), o-nitrotoluene (1250 and 5000 p.p.m.) and… CONTINUE READING

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