Unique pattern of renal κ light chain amyloid deposition with histiocytic transdifferentiation of tubular epithelial cells.

@article{Hemminger2012UniquePO,
  title={Unique pattern of renal κ light chain amyloid deposition with histiocytic transdifferentiation of tubular epithelial cells.},
  author={Jessica Hemminger and Anjali A. Satoskar and Sergey V Brodsky and Edward Calomeni and Gyongyi M Nadasdy and Paul M. Kovach and Craig C. Hofmeister and Tibor Nadasdy},
  journal={The American journal of surgical pathology},
  year={2012},
  volume={36 8},
  pages={
          1253-7
        }
}
Monoclonal gammopathies can cause renal tubular epithelial damage through multiple mechanisms, the most common manifestation being myeloma cast nephropathy. Amyloid light chain amyloidosis rarely affects the renal tubular epithelium directly and usually causes glomerular injury. Amyloid deposition can also be seen within vessel walls and in the renal tubulointerstitium. Herein, we describe a unique pattern of κ light chain amyloid deposition involving the proximal tubule epithelium in a patient… CONTINUE READING
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