Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

@article{Yamamoto1992UniquePS,
  title={Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.},
  author={Seiichiro Yamamoto and Toshiko Yamamoto and Tohru Kataoka and Etsuro Kuramoto and Osamu Yano and Tohru Tokunaga},
  journal={Journal of immunology},
  year={1992},
  volume={148 12},
  pages={4072-6}
}
Thirty-mer single-stranded oligonucleotides, with a sequence chosen from the known cDNA encoding the 64-kDa protein named Ag A or the MPB-70 protein of Mycobacterium bovis BCG and the human cellular proteins such as complement component 1 inhibitor and Ig rearranged lambda-chain, were used to dissect the capability to induce IFN and to augment NK cell activity of mouse spleen cells by coincubation in vitro. Three with the hexamer palindromic sequence as GACGTC were active, whereas two kinds of… CONTINUE READING

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