Unique metabolites of eicosapentaenoic acid interfere with corpus luteum function in the ewe.

@article{Orwig1992UniqueMO,
  title={Unique metabolites of eicosapentaenoic acid interfere with corpus luteum function in the ewe.},
  author={Kyle E. Orwig and S Leers-sucheta and Mehran F. Moghaddam and Z D Jiang and W R Gerwick and Fredrick Stormshak},
  journal={Prostaglandins},
  year={1992},
  volume={44 6},
  pages={
          519-30
        }
}
Effects of flaxseed and defatted flaxseed meal on reproduction and development in rats.
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    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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Biologically active oxylipins from seaweeds
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Red algae metabolize polyunsaturated fatty acids to oxidized products resembling the eicosanoid hormones from mammals, and seaweed-derived oxylipins have potential utility as pharmaceuticals and research biochemicals.
Structure and biosynthesis of marine algal oxylipins.
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The Chemistry of Marine Algae and Cyanobacteria
TLDR
This chapter reviews the major metabolic themes that are characteristic of the prominent groups of marine algae and cyanobacteria and facilitates an appreciation of the uniqueness of each of these groups in their capacity to elaborate specific classes of secondary metabolites.
Long chain polyunsaturated fatty acids and bovine luteal cell function.
TLDR
PUFA have potent inhibitory effects on the production of progesterone and PGI2 in vitro and may play a role in bovine luteal cell function by mechanisms yet to be determined.

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It is concluded that SA acts on the CL to impair steroidogenesis and ultimately cause luteal regression.
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An inhibitor of the lipoxygenase pathway of arachidonic acid metabolism delays luteolysis, possibly by removing the preferential inhibition of PGF1 alpha biosynthesis caused by 5-HETE and other products of the Lipoxidase system.
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Changes in this organelle were reflected by an increased U:S fatty acid ratio in luteal membrane PI during the estrous cycle, and significant differences in unsaturated fatty acids of chain length greater than 20 carbons were detected between NP and P ewes as well as between days within reproductive stage.
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The antiluteolytic effect of prostaglandin (PG) E2 was tested in two experiments and ewes that returned to estrus were necropsied and weights of corpora lutea (CL) obtained.
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It is shown that oxytocin secretion from slices of ovine corpus luteum incubated in vitro is stimulated by exogenous and endogenously released arachidonic acid, which may have its effect via the lipoxygenase pathway.
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It is concluded that oestradiol-17 beta and PGE-2, both of which are produced by the bovine conceptus and secreted from the gravid uterus, may act synergistically to maintain luteal function during early pregnancy in the cow.
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The results suggest that the large cells are the targets of the luteolytic effects of PGF-2 alpha, while the small cells are responsible for the previously reported luteotrophic effect of P GF-2alpha in vitro.
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The distributions of the various plasma membrane markers again indicated a partial dissociations between hCG-binding and adenylate cyclase activities of luteinized rat ovaries, suggesting the existence of two distinct major plasma membrane populations, with different buoyant densities, marker enzyme profiles andAdenylATE cyclase and hormone-binding levels.
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