Unique metabolites of eicosapentaenoic acid interfere with corpus luteum function in the ewe.

@article{Orwig1992UniqueMO,
  title={Unique metabolites of eicosapentaenoic acid interfere with corpus luteum function in the ewe.},
  author={Kyle E. Orwig and S Leers-sucheta and Mehran F. Moghaddam and Z D Jiang and W R Gerwick and Fredrick Stormshak},
  journal={Prostaglandins},
  year={1992},
  volume={44 6},
  pages={
          519-30
        }
}
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6 Citations

Effects of flaxseed and defatted flaxseed meal on reproduction and development in rats.
  • T. CollinsR. Sprando D. Ruggles
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2003
Luteotropic and luteolytic mechanisms in the bovine corpus luteum.
Biologically active oxylipins from seaweeds
TLDR
Red algae metabolize polyunsaturated fatty acids to oxidized products resembling the eicosanoid hormones from mammals, and seaweed-derived oxylipins have potential utility as pharmaceuticals and research biochemicals.
Structure and biosynthesis of marine algal oxylipins.
  • W. Gerwick
  • Environmental Science, Biology
    Biochimica et biophysica acta
  • 1994
The Chemistry of Marine Algae and Cyanobacteria
TLDR
This chapter reviews the major metabolic themes that are characteristic of the prominent groups of marine algae and cyanobacteria and facilitates an appreciation of the uniqueness of each of these groups in their capacity to elaborate specific classes of secondary metabolites.
Long chain polyunsaturated fatty acids and bovine luteal cell function.
TLDR
PUFA have potent inhibitory effects on the production of progesterone and PGI2 in vitro and may play a role in bovine luteal cell function by mechanisms yet to be determined.

References

SHOWING 1-10 OF 21 REFERENCES
In vivo and in vitro effects of a cyclopropenoid fatty acid on ovine corpus luteum function.
TLDR
It is concluded that SA acts on the CL to impair steroidogenesis and ultimately cause luteal regression.
Involvement of lipoxygenase products of arachidonic acid metabolism in bovine luteal function.
TLDR
An inhibitor of the lipoxygenase pathway of arachidonic acid metabolism delays luteolysis, possibly by removing the preferential inhibition of PGF1 alpha biosynthesis caused by 5-HETE and other products of the Lipoxidase system.
Characterization of plasma membrane lipids and luteinizing hormone receptors of ovine corpora lutea during luteolysis and early pregnancy.
TLDR
Changes in this organelle were reflected by an increased U:S fatty acid ratio in luteal membrane PI during the estrous cycle, and significant differences in unsaturated fatty acids of chain length greater than 20 carbons were detected between NP and P ewes as well as between days within reproductive stage.
Effect of continuous intrauterine administration of prostaglandin E2 on life span of corpora lutea of nonpregnant ewes.
TLDR
The antiluteolytic effect of prostaglandin (PG) E2 was tested in two experiments and ewes that returned to estrus were necropsied and weights of corpora lutea (CL) obtained.
Control of oxytocin secretion by ovine corpora lutea: effects of arachidonic acid, phospholipases, and prostaglandins.
TLDR
It is shown that oxytocin secretion from slices of ovine corpus luteum incubated in vitro is stimulated by exogenous and endogenously released arachidonic acid, which may have its effect via the lipoxygenase pathway.
Effects of intrauterine infusion of oestradiol-17 beta and prostaglandin E-2 on luteal function in non-pregnant heifers.
TLDR
It is concluded that oestradiol-17 beta and PGE-2, both of which are produced by the bovine conceptus and secreted from the gravid uterus, may act synergistically to maintain luteal function during early pregnancy in the cow.
Eicosanoids and other hydroxylated fatty acids from the marine alga Gracilariopsis lemaneiformis
Control of progesterone production in small and large bovine luteal cells separated by flow cytometry.
TLDR
The results suggest that the large cells are the targets of the luteolytic effects of PGF-2 alpha, while the small cells are responsible for the previously reported luteotrophic effect of P GF-2alpha in vitro.
Interactions of gonadotropins with corpus luteum membranes. I. Properties and distributions of some marker enzyme activities after subcellular fractionation of the superovulated rat ovary.
TLDR
The distributions of the various plasma membrane markers again indicated a partial dissociations between hCG-binding and adenylate cyclase activities of luteinized rat ovaries, suggesting the existence of two distinct major plasma membrane populations, with different buoyant densities, marker enzyme profiles andAdenylATE cyclase and hormone-binding levels.
Effect of chronic ipsilateral or contralateral intrauterine infusion of prostaglandin E1 (PGE1) on luteal function of unilaterally ovariectomized ewes.
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