Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle.

  title={Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle.},
  author={Lan Wei and Amy D. Hanna and Nicole A Beard and Angela F Dulhunty},
  journal={Cell calcium},
  volume={45 5},
Calcium signaling in myocytes is dependent on the cardiac ryanodine receptor (RyR2) calcium release channel and the calcium buffering protein in the sarcoplasmic reticulum, cardiac calsequestrin (CSQ2). The overall properties of CSQ2 and its regulation of RyR2 have not been explored in detail or directly compared with skeletal CSQ1 and its regulation of the skeletal RyR1, with physiological ionic strength and Ca(2+) concentrations. We find that there are major differences between the two… CONTINUE READING


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