Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells.

@article{Bumol1982UniqueGC,
  title={Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells.},
  author={Thomas F. Bumol and Ralph A. Reisfeld},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 4},
  pages={1245-9}
}
A monoclonal antibody, 9.2.27, with a high specificity for human melanoma cell surfaces has been utilized for biosynthetic studies in M21 human melanoma cells to define a unique antigenic complex consisting of a 250-kilodalton N-linked glycoprotein and a high molecular weight proteoglycan component larger than 400 kilodaltons. The 250-kilodalton glycoprotein has endoglycosidase H-sensitive precursors and shows a lower apparent molecular weight after treatment with neuraminidase. The… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 87 extracted citations

Similar Papers

Loading similar papers…