Unique glomerular lesion with spontaneous lipid deposition in glomerular capillary lumina in the NON strain of mice.

@article{Watanabe1991UniqueGL,
  title={Unique glomerular lesion with spontaneous lipid deposition in glomerular capillary lumina in the NON strain of mice.},
  author={Yoshifumi Watanabe and Yasuhiko Itoh and Futoshi Yoshida and Noritoshi Koh and Hiroshi Tamai and Atsushi Fukatsu and Seiichi Matsuo and Nigishi Hotta and Naoya Sakamoto},
  journal={Nephron},
  year={1991},
  volume={58 2},
  pages={210-8}
}
We found a strain of nonobese, nondiabetic (NON) mice which has spontaneous lipid deposition in glomerular capillary lumina. This strain was developed together with a diabetic strain of nonobese diabetic (NOD) mice for the generation of mouse models of diabetes mellitus. In the NON strain, contrary to the name, impaired glucose tolerance (IGT) was observed in about half of the mice. Meanwhile, peculiar glomerular abnormalities which remotely resemble those of diabetic nephropathy were observed… CONTINUE READING

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