Unique gene alterations are induced in FACS-purified Fos-positive neurons activated during cue-induced relapse to heroin seeking.

@article{Fanous2013UniqueGA,
  title={Unique gene alterations are induced in FACS-purified Fos-positive neurons activated during cue-induced relapse to heroin seeking.},
  author={Sanya Fanous and Danielle H. Guez-Barber and Evan M Goldart and Regina Schrama and Florence R. M. Theberge and Yavin Shaham and Bruce T Hope},
  journal={Journal of neurochemistry},
  year={2013},
  volume={124 1},
  pages={
          100-8
        }
}
Cue-induced heroin seeking after prolonged withdrawal is associated with neuronal activation and altered gene expression in prefrontal cortex (PFC). However, these previous studies assessed gene expression in all neurons regardless of their activity state during heroin seeking. Using Fos as a marker of neural activity, we describe distinct molecular alterations induced in activated versus non-activated neurons during cue-induced heroin seeking after prolonged withdrawal. We trained rats to self… CONTINUE READING
BETA

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Similar Papers

Loading similar papers…