Unique function for carboxyl-terminal domain of Oct-2 in Ig-secreting cells.

@article{Sharif2001UniqueFF,
  title={Unique function for carboxyl-terminal domain of Oct-2 in Ig-secreting cells.},
  author={M. Nusrat Sharif and Hanna S. Radomska and Daniel M. Miller and Laurel A. Eckhardt},
  journal={Journal of immunology},
  year={2001},
  volume={167 8},
  pages={4421-9}
}
The activity of Ig gene promoters and enhancers is regulated by two related transcription factors, Oct-1 (ubiquitous) and Oct-2 (B lineage specific), which bind the octamer motif (ATTTGCAT) present in these elements. As Ig promoter-binding factors, Oct-1 and Oct-2 each work together with a B lymphocyte-specific cofactor OCA-B/OBF-1/Bob-1 that interacts with them through their POU (DNA-binding) domains. Because both can mediate Ig promoter activity in B cells, there has been some question as to… CONTINUE READING

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