Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers

@inproceedings{Sun2014UniqueEF,
  title={Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers},
  author={YuChen Sun and Tomomi Furihata and Seiya Ishii and Miki Nagai and Manami Harada and Osamu Shimozato and Takehiko Kamijo and Shinichiro Motohashi and Ichiro Yoshino and Atsuko Kamiichi and Kaoru Kobayashi and Kan Chiba},
  booktitle={Clinical and translational medicine},
  year={2014}
}
BACKGROUND We have previously identified the cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in several human colon and lung cancer tissues. Ct-OATP1B3 is a variant of the liver-type OATP1B3 (Lt-OATP1B3) mRNA, which is a hepatocyte plasma membrane transporter with broad substrate specificity. However, in cancer tissues, both the detailed characteristics of Ct-OATP1B3 mRNA expression and its biological functions remain unclear. With this point in mind, we sought to… CONTINUE READING
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