Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole.

@article{Biegon2010UniqueDO,
  title={Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole.},
  author={Anat Biegon and Sung Won Kim and David L. Alexoff and Millard Jayne and Pauline Carter and Barbara Hubbard and Payton King and Jean Logan and Lisa Muench and Deborah Pareto and David Schlyer and Colleen Shea and Frank Telang and Gene-Jack Wang and Youwen Xu and Joanna S. Fowler},
  journal={Synapse},
  year={2010},
  volume={64 11},
  pages={801-7}
}
Aromatase catalyzes the last step in estrogen biosynthesis. Brain aromatase is involved in diverse neurophysiological and behavioral functions including sexual behavior, aggression, cognition, and neuroprotection. Using positron emission tomography (PET) with the radiolabeled aromatase inhibitor [N-methyl-(11)C]vorozole, we characterized the tracer distribution and kinetics in the living human brain. Six young, healthy subjects, three men and three women, were administered the radiotracer alone… CONTINUE READING

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