Unique conformation of cancer autoantigen B23 in hepatoma: a mechanism for specificity in the autoimmune response.

@article{Ulanet2003UniqueCO,
  title={Unique conformation of cancer autoantigen B23 in hepatoma: a mechanism for specificity in the autoimmune response.},
  author={Danielle B. Ulanet and Michael S. Torbenson and Chi V. Dang and Livia A. Casciola-Rosen and Antony Rosen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 21},
  pages={
          12361-6
        }
}
The association of a specific autoantibody response with distinct disease phenotypes is observed in both autoimmune diseases and cancer. Although the underlying mechanisms remain unclear, it is likely that unique properties of disease-specific autoantigens expressed in the relevant target cells play a role. It has recently been observed that the majority of autoantigens targeted across the spectrum of systemic autoimmune diseases (but not nonautoantigens) are selectively cleaved by the… CONTINUE READING

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