Unique cell lines harbouring both Epstein–Barr virus and adult T-cell leukaemia virus, established from leukaemia patients

@article{Yamamoto1982UniqueCL,
  title={Unique cell lines harbouring both Epstein–Barr virus and adult T-cell leukaemia virus, established from leukaemia patients},
  author={Naoki Yamamoto and Tadashi Matsumoto and Yoshio Koyanagi and Yuetsu Tanaka and Yorio Hinuma},
  journal={Nature},
  year={1982},
  volume={299},
  pages={367-369}
}
Members of three distinct classes of animal virus have been associated with naturally occurring neoplasias in man: Epstein–Barr virus (EBV)1, a DNA virus belonging to herpesvirus group, papillomavirus2, and a novel human RNA (retro) virus3–8, human T-cell leukaemia virus or adult T-cell leukaemia (ATL) virus. We have established seven continuous cell lines from ATL patients and 0.1–7% of these cells consistently express ATL-specific antigens (ATLA)8,9. EBV-associated nuclear antigen (EBNA)10 is… CONTINUE READING

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