Unique biological properties of Mycobacterium tuberculosis L-form variants: impact for survival under stress.

@article{Markova2012UniqueBP,
  title={Unique biological properties of Mycobacterium tuberculosis L-form variants: impact for survival under stress.},
  author={Nadya D. Markova and Georgi Slavchev and Lilia Michailova},
  journal={International microbiology : the official journal of the Spanish Society for Microbiology},
  year={2012},
  volume={15 2},
  pages={61-8}
}
Bacteria can, under certain conditions, enter into a cell-less state known as L-form conversion. This phenomenon is universal, but also recognized with difficultly by microbiologists. The current study addresses several aspects concerning the ability of tubercle bacilli to use L-form conversion as a unique adaptive strategy to survive and reproduce under unfavorable conditions. Nutrient starvation of M. tuberculosis in vitro followed by passages in Middlebrook 7H9 semisolid medium was used for… CONTINUE READING

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