Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors.

@article{Malmberg1993UniqueBC,
  title={Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors.},
  author={Asa Malmberg and David M. Jackson and Asa Eriksson and Nina Mohell},
  journal={Molecular pharmacology},
  year={1993},
  volume={43 5},
  pages={749-54}
}
In the present study we have compared the pharmacological properties of human dopamine (DA) D2A, D2B, and D3 receptors expressed in mammalian cell lines, using [3H]raclopride as a radioligand. Most of the compounds tested had about equal affinity for D2A and D3 receptors, with the exception of remoxipride, which displayed a 10-fold D2 selectivity, and the aminotetralin (+)-UH 232, which displayed a 5-fold D3 selectivity. Several antipsychotic agents, including clozapine and substituted… CONTINUE READING

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