Unique antiplatelet effects of a novel S-nitrosoderivative of a recombinant fragment of von Willebrand factor, AR545C: in vitro and ex vivo inhibition of platelet function.

@article{Inbal1999UniqueAE,
  title={Unique antiplatelet effects of a novel S-nitrosoderivative of a recombinant fragment of von Willebrand factor, AR545C: in vitro and ex vivo inhibition of platelet function.},
  author={Amir Inbal and Osnat T Gurevitz and Ilia Tamarin and Regina Eskaraev and Angela Chetrit and I Novicov and Michael Feldman and David Varon and Michael Eldar and Joseph Loscalzo},
  journal={Blood},
  year={1999},
  volume={94 5},
  pages={1693-700}
}
The recombinant fragment of von Willebrand factor (vWF) spanning Ala444 to Asp730 and containing an Arg545Cys mutation (denoted AR545C) has antithrombotic properties that are principally a consequence of its ability to inhibit platelet adhesion to subendothelial matrix. Endothelial-derived nitric oxide (NO) can also inhibit platelet function, both as a… CONTINUE READING