Unique anti-human immunodeficiency virus activities of the nonnucleoside reverse transcriptase inhibitors calanolide A, costatolide, and dihydrocostatolide.

@article{Buckheit1999UniqueAI,
  title={Unique anti-human immunodeficiency virus activities of the nonnucleoside reverse transcriptase inhibitors calanolide A, costatolide, and dihydrocostatolide.},
  author={Robert W. Buckheit and E. Lucile White and V Fliakas-Boltz and Julie D Russell and T L Stup and Tracy Kinjerski and M Clayton Osterling and Ann Weigand and John P. Bader},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 8},
  pages={1827-34}
}
(+)-Calanolide A (NSC 650886) has previously been reported to be a unique and specific nonnucleoside inhibitor of the reverse transcriptase (RT) of human immunodeficiency virus (HIV) type 1 (HIV-1) (M. J. Currens et al., J. Pharmacol. Exp. Ther., 279:645-651, 1996). Two isomers of calanolide A, (-)-calanolide B (NSC 661122; costatolide) and (-)-dihydrocalanolide B (NSC 661123; dihydrocostatolide), possess antiviral properties similar to those of calanolide A. Each of these three compounds… CONTINUE READING

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