Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety.

@article{He2013UniqueAH,
  title={Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety.},
  author={Ran He and Michael J. Forman and Bryan T. Mott and Rajkumar Venkatadri and Gary H. Posner and Ravit Arav-Boger},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 9},
  pages={4208-14}
}
We report that the artemisinin-derived dimer diphenyl phosphate (DPP; dimer 838) is the most selective inhibitor of human cytomegalovirus (CMV) replication among a series of artemisinin-derived monomers and dimers. Dimer 838 was also unique in being an irreversible CMV inhibitor. The peroxide unit within artemisinins' chemical structures is critical to their activities, and its absence results in loss of anti-CMV activities. Surprisingly, the deoxy dimer of 838 retained modest anti-CMV activity… CONTINUE READING

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