Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage

@article{Snijder2003UniqueAC,
  title={Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage},
  author={Eric J. Snijder and Peter J. Bredenbeek and Jessika C. Dobbe and Volker Thiel and John Ziebuhr and Leo L. M. Poon and Yi Guan and Mikhail Rozanov and Willy J. M. Spaan and Alexander E. Gorbalenya},
  journal={Journal of Molecular Biology},
  year={2003},
  volume={331},
  pages={991 - 1004}
}
Abstract The genome organization and expression strategy of the newly identified severe acute respiratory syndrome coronavirus (SARS-CoV) were predicted using recently published genome sequences. Fourteen putative open reading frames were identified, 12 of which were predicted to be expressed from a nested set of eight subgenomic mRNAs. The synthesis of these mRNAs in SARS-CoV-infected cells was confirmed experimentally. The 4382- and 7073 amino acid residue SARS-CoV replicase polyproteins… Expand

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