Unique action determinants of double acting topoisomerase inhibitor, TAS-103.

Abstract

O6-methylguanine-DNA methyltransferase (MGMT), gamma-glutamylcysteine synthetase (gamma-GCS), and glutathione (GSH) are found to participate in resistance to TAS-103, a topoisomerase I/II inhibitor. In 13 human cancer cell lines, MGMT expression correlated with IC50 for TAS-103, whereas gamma-GCS expression inversely correlated with the IC50 value… (More)

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Cite this paper

@article{Okamoto2001UniqueAD, title={Unique action determinants of double acting topoisomerase inhibitor, TAS-103.}, author={Ryuji Okamoto and Hajime Takano and Takashi Sekikawa and Tomohiro Tanaka and M Toyada and Kei Ukon and Kotaro Tanimoto and Tatsuo Kumazaki and Masahiko Nishiyama}, journal={International journal of oncology}, year={2001}, volume={19 5}, pages={921-7} }