Unique Spatiotemporal Neuromodulation of the Lumbosacral Circuitry Shapes Locomotor Success after Spinal Cord Injury.

@article{Shah2016UniqueSN,
  title={Unique Spatiotemporal Neuromodulation of the Lumbosacral Circuitry Shapes Locomotor Success after Spinal Cord Injury.},
  author={Prithvi K. Shah and Shakthi Sureddi and Monzurul Alam and Hui Zhong and Roland R. Roy and V. Reggie Edgerton and Yury P. Gerasimenko},
  journal={Journal of neurotrauma},
  year={2016},
  volume={33 18},
  pages={1709-23}
}
Spinal cord epidural stimulation has resulted in the initiation of voluntary leg movements and improvement in postural, bladder, and sexual function. However, one of the limitations in reaching the full potential of epidural stimulation for therapeutic purposes in humans has been the identification of optimal stimulation configurations that can neuromodulate the spinal cord for stepping. In the present work, we investigated the mechanisms underlying the specificity of interaction between the… CONTINUE READING