Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity.

@article{Suzuki2008UniqueSA,
  title={Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity.},
  author={Takayuki Suzuki and Sean M. Hasso and John F. Fallon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 11},
  pages={4185-90}
}
The zone of polarizing activity is the primary signaling center controlling anterior-posterior patterning of the amniote limb bud. The autopodial interdigits (IDs) are secondary signaling centers proposed to determine digit identity by acting on the cells of the digital ray. Here, we focus on events accompanying digital fate determination and define a region of the digital ray that expresses Sox9 and Bmpr1b and is phosphorylated-SMAD1/5/8 (p-SMAD1/5/8) positive. We name this region the phalanx… CONTINUE READING

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