Unique Roles of Phosphorus in Endochondral Bone Formation and Osteocyte Maturation

Abstract

The mechanisms by which inorganic phosphate (P(i)) homeostasis controls bone biology are poorly understood. Here we used Dmp1 null mice, a hypophosphatemic rickets/osteomalacia model, combined with a metatarsal organ culture and an application of neutralizing fibroblast growth factor 23 (FGF-23) antibodies to gain insight into the roles of P(i) in bone… (More)
DOI: 10.1002/jbmr.294

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