Unique Lamina Propria Stromal Cells Imprint the Functional Phenotype of Mucosal Dendritic Cells

  title={Unique Lamina Propria Stromal Cells Imprint the Functional Phenotype of Mucosal Dendritic Cells},
  author={Ildefonso Vicente-Suarez and Alexandre Larange and Colin Reardon and Michael H. Matho and Sonia Feau and Grzegorz Chodaczek and Yunji Park and Yuuki Obata and Rebecca Gold and Yiran Wang-Zhu and Chris Lena and Dirk M. Zajonc and Stephen P. Schoenberger and Mitchell Kronenberg and Hilde Cheroutre},
  booktitle={Mucosal Immunology},
Mucosal dendritic cells (DCs) in the intestine acquire the unique capacity to produce retinoic acid (RA), a vitamin A metabolite that induces gut tropism and regulates the functional differentiation of the T cells they prime. Here, we identified a stromal cell (SC) population in the intestinal lamina propria (LP), which is capable of inducing RA production in DCs in a RA- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent fashion. Unlike DCs, LP SCs constitutively expressed… CONTINUE READING
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