Unique Inner Pore Properties of BK Channels Revealed by Quaternary Ammonium Block

@article{Li2004UniqueIP,
  title={Unique Inner Pore Properties of BK Channels Revealed by Quaternary Ammonium Block},
  author={Weiyan Li and Richard W. Aldrich},
  journal={The Journal of General Physiology},
  year={2004},
  volume={124},
  pages={43 - 57}
}
Potassium channels have a very wide distribution of single-channel conductance, with BK type Ca(2+)-activated K(+) channels having by far the largest. Even though crystallographic views of K(+) channel pores have become available, the structural basis underlying BK channels' large conductance has not been completely understood. In this study we use… CONTINUE READING